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In the smooth muscle cell GMP is always present, when Nitric Oxide enters the smooth muscle cell it converses GMP into cyclic GMP (c GMP), which causes an erection.

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For the treatment of pulmonary arterial hypertension. It initially was developed by the biotechnology company ICOS, and then again developed and marketed world-wide by Lilly ICOS, LLC, the joint venture of ICOS Corporation and Eli Lilly and Company.

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Cialis, Levitra (Vardenafil) and Viagra (Sildenafil) work by selectively inhibiting an enzyme in the penis ed Phosphodiesterase V (PDE V), a chemical that takes away the erection.

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